Motto of the day
Peter Mere Latham
Publishing house: International Journal of Hyperthermia
Main author: Yoko Harima
Other authors: Takayuki Ohguri, Hajime Imada, Hideyuki Sakurai, Tatsuya Ohno, Yoshiyuki Hiraki, Koh Tuji, Masahiro Tanaka & Hiromi Terashima
Publication class: Clinical study
Research type: Randomized, multicenter
Number of patients: 101
HT type: LRHT Capacitive
Description of HT type: Local HT, deep, capacitive
Device: Thermotron RF-8
Disease entity: Locally advanced cervical cancer
Symbol of disease entity: LACC
Types of combination with HT: HT+RT+CT
CT type: Cisplatin
Abstract. Background and purpose: To evaluate the effectiveness of whole-pelvic hyperthermia (HT) added to standard chemoradiotherapy (CRT) in locally advanced cervical cancer (CC), by investigating the clinical response and survival of patients treated with cisplatin-based CRT vs. CRT with HT (CRTþHT).
Materials and methods: This study was conducted at five hospitals in Japan between September 2001 and March 2015 in patients with the International Federation of Gynecology and Obstetrics stage IB (bulky)–IVA CC undergoing definitive CRT. After giving a written informed consent, patients were randomly allocated to two treatment groups: CRT and CRTþHT group. Overall survival (OS), diseasefree survival (DFS), local relapse-free survival (LRFS), complete response (CR) rate and tolerability were evaluated.
Results: In total, 101 patients were treated. Patient characteristics, total dose of cisplatin and radiotherapy were similar for both groups. Although not statistically significant, the 5-year OS, DFS and LRFS in the CRTþHT group (77.8%, 70.8% and 80.1%, respectively) were better than those in the CRT group (64.8%, 60.6% and 71.0%, respectively). CR was significantly more likely to be achieved in patients in the CRTþHT group than in the CRT group (88% vs. 77.6%; adjusted odds ratio, 3.993; 95% confidence interval, 1.018–15.67; p¼.047). CRTþHT was well tolerated and caused no additional acute or longterm toxicity compared with CRT alone.
Conclusions: HT combined with CRT improved the CR rate of CRT in patients with locally advanced CC, however, could not improve survival outcomes. Further studies in larger samples are warranted.
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